The inhibitory microcircuit of the substantia nigra provides feedback gain control
Dysfunction of the basal ganglia produces severe deficits in the timing, initiation, and vigor of movement. These diverse impairments suggest a control system gone awry.
In engineered systems feedback is critical for stable control.
Here we show that one feedback pathway, axon collaterals of substantia nigra projection neurons, control the gain of the basal ganglia output.
The importance of feedback for engineered control systems implies that the intranigral microcircuit could be essential to normal basal ganglia function.